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2020 Volume 11 Issue 2

Evidence that supports the antidiabetic, antihypertensive, and antihyperlipidemic effects of olive (Olea europaea L.) leaves extract and its active constituents (oleuropein) in human


Heba A. Sindi
Abstract

The Kingdom of Saudi Arabia is one of the countries in the Middle East burdened with type 2 diabetes (T2D). This type of diabetes is associated with an increase in the body's resistance to insulin action. Elevated blood pressure is one of the most important diseases that accompany T2D. Many experimental and clinical studies have shown the effectiveness of olive leaves extract (OLEx) in controlling T2D, as well as hypertension. This review aimed to collect clinical studies conducted in humans that prove the effectiveness of OLEx or its active constituent (oleuropein) in combating T2D, hypertension, and hypolipidemia. Several studies conducted in humans (diseased and healthy) showed the effectiveness of OLEx or oleuropein in reducing both blood glucose and lipids. It also improved the vascular functions and reduced inflammation associated with high blood pressure and diabetes. The mechanisms behind these pharmacological activities were to scavenge free radicals, increase insulin production, and reduce its resistance, raise nitric oxide synthesis, and dilate blood vessels. From toxicological studies in experimental animals, it has been shown that the OLEx may be safe to use. In conclusion, studies on humans showed the effectiveness of OLEx in managing T2D, hyperlipidemia, and hypertension, but there were limited-number trials and did not use large numbers of participants, and therefore large studies must be conducted to document effectiveness and safety of OLEx.


How to cite this article
Sindi H A. Evidence that supports the antidiabetic, antihypertensive, and antihyperlipidemic effects of olive (Olea europaea L) leaves extract and its active constituents (oleuropein) in human. J Biochem Technol 2020;11(2):41-5
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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative