Quick access

PDF
Share Article:
2014 Volume 5 Issue 4

Enhanced safety and protection of glutamate induced hippocampal neuronal cells damage by Neurotol


Abstract
p { margin-bottom: 0.21cm; }We investigated the neuroprotective effect of Neurotol (Mannitol 10% + Glycerin 10% + RD011 1.5 %) against neuronal damage induced by glutamate compared to Neurotol M (Mannitol 20%), Kratol and Zemisol. Exposure of neuronal cells to glutamate caused concentration dependent neuronal damage as evident by significant increase in LDH activities (P<0.05 to P<0.001). The neuronal cell toxicity by exposure to glutamate involves an apoptotic process. However, among the tested drugs, 100 µM of Neurotol significantly prevented the neuronal cells from glutamate toxicity (P<0.001) indicating Neurotol is fully effective in neuronal cell protection. When various drugs were compared for their involvement in regulation of MAP2 expression, Neurotol was found to significantly up regulate the expression of MAP2, after 6 h of treatment (P<0.05) and was continued upto 24 hrs which was comparable with normal cells at 24 hrs. Therefore, neurotol may become a potential therapy candidate in brain disorders or damage.

INDEXING
+ Pubmed Central, DOAJ, SCIRUS, BiologyBrowser, Chemical Abstracts, CABI, Intute catalogue, Science Central, EBSCOhost databases, Google Scholars, Genamics JournalSeek, Open J gate, Ulrich's, ResearchGate and many more.

J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

Publish with us

Call for papers

Issue 3 Volume 11 - 2020

Publishing steps

1.Prepare
your paper
2.Submit
and revise
3.Track
your research
4.Share
and promote
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative