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2019 Volume 10 Issue 4

Design and Synthesis of Two Methylthiosteroid-Oxirenol Derivatives: Theoretical ‎Evaluation of Their Interaction with B1-Cannabinoid Receptor


Figueroa-Valverde Lauro, Diaz-Cedillo Francisco, Rosas-Nexticapa Marcela, Garcimarero-Espino E. ‎Alejandra, Mateu-Armand Virginia, Lopez-Ramos Maria, Hau-Heredia-Lenin, Estrella- Barron Raquel, ‎Borges-Ballote Yaritza
Abstract

Several agonists and antagonists of B1 cannabinoid receptors have been synthesized for the treatment of several clinical pathologies such as psychosis, hyperalgesia, and drug addiction; however, some of these drugs may produce some side effects including higher intraocular pressure, hepatotoxicity, etc. The aim of this study was to synthesize two new methylthiosteroid-oxirenol derivatives (compounds 7 and 8) to evaluate their theoretical interaction with B1 cannabinoid receptor (5gtz) using WIN-55,212-2, yangonin, cannabigerol, and tetrahydrocannabivarin drugs as controls in a docking model. The preparation of 7 and 8 were carried out using a series of reactions which involved nitration, etherification, hydrogenation-chlorination, and addition. The chemical structure of the compounds was confirmed using elemental analysis and NMR spectrum. The results showed that compound 7 or 8 could bind to different types of amino acid residues involved in 5gtz protein surface compared with the WIN 55,212-2, Yangonin, Cannabigerol, and Tetrahydrocannabivarin drugs. All data suggest that compound 7 or 8 may exert changes in the biological activity of B1 cannabinoid receptor‎‎.


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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative