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2020 Volume 11 Issue 4

Connexion of Thrombomodulin Gene -33G/A Polymorphism and the Risk of Coronary Artery Disease


Ola Elmahi Omer, NasrEldeen Ali Mohammed, Sara Abdelghani, Lienda Bashier Eltayeb, Hisham Ali Waggiallah
Abstract

Coronary Artery Disease (CAD) is caused by plaque buildup in the wall of the arteries that carry blood to the heart. Aim: This is an analytical case-control study carried out at Al-Neelain University and samples from Sudan Heart center, Khartoum, Sudan, during November 2018 and aimed to detect the association of thrombomodulin G33A polymorphism and CAD. A total of 80 subjects have participated in the current research. 40 of them were known Sudanese Patients diagnosed with Coronary Artery Disease, admitted to Sudan heart center, 21(52.5%) were males and19 (47.5%) were females; their mean age is 56.6 years. Other 40 normal healthy volunteers similar in gender and age the case group used as a control group. 2.5 ml of EDTA anticoagulated blood was collected from all participants. DNA was extracted by the salting-out method. Then the detection of thrombomodulin G33A polymorphism using allele-specific Polymerase Chain Reaction. The data were obtained by using a directly structured interviewer questionnaire. Data were analyzed via (SPSS) software version 25. This study revealed that the thrombomodulin gene G33A polymorphism was statistically significantly associated with Sudanese patients with CAD (p value=0.00). This study concludes that the thrombomodulin G33A polymorphism predicts as a risk factor of the development of CAD in Sudanese patients.


How to cite this article
Omer O E, Mohammed N A, Abdelghani S, Eltayeb L B, Waggiallah H A. Connexion of Thrombomodulin Gene -33G/A Polymorphism and the Risk of Coronary Artery Disease. J Biochem Technol 2020;11(4):89-92
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative