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2009 Volume 1 Issue 3

CMP Promoters Database: A systematic study on site-specific transcription factors in CMP genes


Abstract
CMPP Database (Central Metabolic Pathway Promoter Database) consists of manually annotated regulatory sequences/motif of genes controlling Metabolic Pathways (http://cmpp.biodbs.info) such as Glycolysis’ and Krebs’ cycle. The CMPP software package written in Microsoft Visual Basics & MS Access was also developed for searching & updating the CMPP database. This database was further used to study the relationship between 10 transcription factors involved in the non-coding upstream region of CMP genes. There is an existence of common motifs between the genes encoding enzymes involved in glycolysis and Krebs cycle revealing an evolutionary relation between the genes of the two pathways. However, some of the common motif such as TATA uncommon motifs as NKX and AP2 making up the structural feature of the non coding genes are absent from few genes. Keywords: Non-coding sequence, Phylogeny, TCA, Glycolysis, TRANSFAC, Promoter, Database, Central Metabolic Pathway. Received: 17 March 2008 / Received in revised form: 5 February 2009, Accepted: 31 April 2009 Published online: 14 May 2009

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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

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FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative