Background: Acne is sorted as a predominant dermatological disorder in young adults, that is either triggered by hormonal, genetic influence, different sex, and environmental factors. There are various topical therapies, systemic treatments, physical modalities, and photodynamic procedures that are best studied and are recommended to aid in the healing process of acute, moderate, and severe forms of acne. Objective: To assist family medicine practitioners to approach acne by defining the differential diagnosis, grading systems, and therapeutic modalities. Methodology: This medical literature was collected and analyzed using published data on the electronic database of PubMed. Any relevant articles, journals, and randomized controlled trials were included in this review. terms were called on abstract or title (( “Acne "[Mesh] AND “Adult” Mesh] AND “Hormonal"[Mesh]AND “GAGS”[Mesh] AND “IGA"[Mesh]AND “Pathogenesis”[Mesh] “Diagnosis”[Mesh] AND “Isotretinoin"[Mesh]AND “Topical”[Mesh])) Conclusion: Family medicine practitioners must lean on evidence-based guidelines to reach treatment goals. In diagnosing acne, defining the differential diagnosis, grading systems of acne and treatment modalities, and their impact are mandatory to reach effective and satisfactory results.