Adsorption of hemoglobin, fatty acid and glucose to iron nanoparticles as a mean for drug delivery


Abstract

Recent research in biomedicine has documented the application of iron-based nano-particles in supplying the human body with essential nutrients or in drug delivery systems.   In this work, the possibility of using iron nanoparticles sorption of biomaterial, such as hemoglobin, cholesterol, triglyceride, serum albumin, and glucose, to cure some specific syndromes have been studies. Bradford assay was used for protein adsorption measurement in supernatant, and FTIR was used for studying the ligands attached to iron nanoparticle. Cholesterol kit and Triglyceride kit were used to measure the cholesterol and triglyceride in supernatant. The result showed that glucose was adsorbed, and the remaining polysaccharide left in supernatant was 42%. Also sorption of triglyceride, cholesterol and serum albumin by nanoparticles was 69%, 73.3% and 87% respectively. FTIR showed hemoglobin being adsorbed to nanoparticles as a ligand. These results indicate that iron nano particles have the capability of being used as a delivery system for biomaterials.  



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