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2020 Volume 11 Issue 2

A saga of Hepcidin anti-microbial Effectiveness as Iron Acquisitor and Anemia Initiator in Mycobacterium Tuberculosis Infection


Hisham Ali Waggiallah, Lienda Bashier Eltayeb, Abdulkarim S. BinShaya, Osman Mohammed Elmahi
Abstract

Hepcidin controls the systemic level of iron as well as the transfer of tissue iron by binding ferroportin to the iron exporter, which allows it to be depleted. Iron is an important element needed by all organisms because of its role in a range of critical cellular biochemical pathways such as DNA production and respiration. Iron is available to both host and pathogen during Mycobacterium tuberculosis (TB) infection. Tuberculosis may have an influence on the contagious result. Both the host and M. tuberculosis require iron, TB should be capable of trapping iron from the host, and the host must modify its iron spread in consequence to infection. This reallocation could act as a protection mechanism against some infectious agents. Even so, hepcidin exquisites the iron intracellular macrophage and the reticuloendothelial system as a protection mechanism for TB infection. Anemia of chronic disease (ACD) is anemia that occurs in acute or chronic immune disorders such as TB and is the second most common in iron deficiency anemia. Several research has reported the prevalence of anemia in patients with TB, and there is some indication that anemia in the diagnosis of TB is correlated with a higher risk of death, and it is also necessary to identify the factors that lead to TB-related anemia.


How to cite this article
Waggiallah H A, Eltayeb L B, BinShaya A S, Elmahi O M. A saga of Hepcidin anti-microbial Effectiveness as Iron Acquisitor and Anemia Initiator in Mycobacterium Tuberculosis Infection. J Biochem Technol 2020;11(2):128-34
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative