Introduction: Osteoarthritis is one of the most common causes of chronic pain in an aging population, and controlling it is a must. Several methods are tried and tested every year. Osteoarthritis has an inflammatory element. Boswellia Serrata has many known Anti-Inflammatory properties. The goal of this study is to compare the effect of a formulation containing Boswellia Serrata extract on the Osteoarthritis patients’ pain alleviation and quality of life improvement with Placebo and Piroxicam Gel. Methods & Materials: 60 patients were gathered in three groups in a Randomized double blinded randomized trial. The study went on for 1 month and each patient was visited by a rheumatologist at inception, days 5, 15 and 30. Routine checkups were done at each visit and patients with known medical conditions were excluded. At the start and at the end of the study liver function tests were taken. The results were then compared with each other and previous visits. Results: Piroxicam was a suitable choice for patients even in short term. It had an acceptable efficacy in improving patient’s pain and improving functions, while Boswellia Serrata Extract did not cause statistically significant difference, except in Visual Analog Scale. While placebo caused some improvement in patients, it could be a result of patients’ overall low level of education.
