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2018 Volume 9 Issue 3

The Use of Plasma Apelin Alteration in Diagnosis of Atherosclerosis

Abdullah Muhsin Hazbar, Khalid Shaalan Sahab
Apelin is a bioactive peptide. Apelin and its receptor APJ are widely distributed in different cell tissues, and involved in a wide range of functions in the cardiovascular system. In this study we investigated whether plasma apelin and some other parameters of coronary artery diseases (lipid profile, creatinine kinase "CK-MB", lactate dehydrogenase "LDH", Troponin T "Tn-T", and High Sensitivity C-reactive protein "hs-CRP") levels were altered in plasma of normal and atherosclerotic subjects. We also assessed the association between plasma apelin and other body parameters in these subjects. Methods: The study included 60 patients with coronary artery disease. Patients compared with 24 healthy subjects as control group. The apelin and Tn-T were estimated by competitive ELISA test using commercially available kit. lipid profile, CK-MB, LDH, and hs-CRP were estimated by colorimetric method. Lipid profiles were determined by using available commercial kits. Results: Plasma levels of apelin in patients were significantly lower (p<0.05) than controls. While, CK-MB, LDH, Tn-T and hs-CRP show significant elevation (P<0.05) in patients compared to control group. Plasma levels of total Cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and Triglyceride (TG) were significantly higher (p<0.05) in patients as compared to control group. However, high density lipoprotein (HDL) in patients shows significant decreasing (P<0.05) in comparison to control. Apelin shows no significant correlation with other body parameters in these patients. Conclusion: In this study obtained apelin levels were found to be significantly lower in patients as compared to control group, but not correlated with other studied parameters in patients. Decreasing apelin may be one of the causes for development of vascular disease, or decreasing apelin may be another factor increasing atherosclerotic process, and can be used for diagnosing Atherosclerosis.

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Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative