To clarify gender differences in the status of patients suffering from stage 1 and 2 arterial hypertension, 80 patients of the second mature age suffering from arterial hypertension were examined. They were divided into 2 groups. The first included 44 patients with stage 1 arterial hypertension, and the second group included 36 patients with stage 2 of the disease. In both sexes, in the case of stage 1 arterial hypertension, the level of arterial pressure corresponds to stage 1. At stage 2, blood pressure values in men are at the level of 1 degree, and in women, they correspond to 2 degrees. The amounts of total cholesterol and cholesterol in the composition of low-density lipoproteins were above the normative level and prevailed in women of both groups. At the 1st stage of hypertension in women, there was a more pronounced imbalance in the amounts of thromboxane B2 and 6-keto-prostaglandin F1α, which was aggravated during the growth of the pathology stage. In men, glomerular filtration was preserved in both groups. From the very beginning of the disease in women, it was reduced, gradually worsening with the progression of the disease. The thickness of the vascular intima and copper in women already at stage 1 was higher than in men and increased with the severity of the pathology. It can be thought that in women, already during the formation of arterial hypertension, more obvious and rapidly developing negative changes in the body appear than in men.