Background and aim: Spiritual health is the newest recognized health aspect. Considering the importance of spiritual health in improving student mental health, as well as the lack of adequate research in this field, we decided to do a study in this regard. Therefore, the present study was conducted with the aim of investigating the relationship between spiritual health and depression in nursing and midwifery students, so that the results could be used for more accurate and more systematic planning for controlling depression and promoting spiritual well-being of students. Materials and Methods: This cross-sectional descriptive study was conducted on 254 nursing and midwifery students of Zabol University of Medical Sciences. In this study, census method was used for sampling. For data collection, three demographic questionnaires, spiritual well-being and Beck Depression Inventory were used. After collecting the data, the spss version 24 was downloaded. The information was described using descriptive statistics and in the form of mean, standard deviation, and percentile percentage. Spearman correlation coefficient and Chi-square test were used in inferential statistics. P value <0.05 was considered as a significant level. Results: The mean and standard deviation of age was 21.54 ± 4.38. The mean and standard deviation of mental health was reported as 96.06 ± 11.69. The mean and standard deviation of depression among students were 10.74 ± 10.02. According to Spearman's correlation coefficient, there was a significant and inverse relation between spiritual health and depression (p-value <0.001, r = -0.271), which means that with increasing spiritual well-being, depression decreased. Conclusion: According to the results of the research, strengthening of spiritual health is one of the preventive ways of developing psychological disorders such as depression.
