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2019 Volume 10 Issue 4

The Relationship Between Serum Zinc and Magnesium Levels and Depression in ‎Postmenopausal Women


Fatemeh Nazari, Khadijeh Hekmat‎‏*‏, Mina Iravani, Mohammad Hosein Haghighizadeh, ‎Hatam Boostani
Abstract

Background and Objective: Depression is the most common mental disorder in ‎different societies, and it is estimated to be the second most common disease followed ‎by cardiovascular disease by 2020. Zinc and magnesium may play a role in the ‎pathophysiology of depression. Therefore, the present study was designed to ‎investigate the relationship between serum zinc, magnesium, and depression in ‎postmenopausal women.‎ Materials and Methods: This was a case-control study of 68 depressed women ‎and 68 non-depressed women. At first, after completing the informed consent and ‎demographic questionnaire and the Beck Depression Inventory, the blood samples were ‎collected, centrifuged and frozen. Then, the zinc and magnesium levels were evaluated ‎by the flame atomic absorption technique. Data were analyzed using SPSS-Ver22, chi-square test, independent t-test, and logistic regression. P values < 0.05 was considered ‎significant.‎ Results: The mean serum zinc and magnesium levels were 88.26 ± 21.21 µg/dl,‎‏ ‏‎1. 82± ‎‎0/49 mg/dl in case group and 102.64 ± 24.41 µg/dl, 2.17 ± 0.57 mg/dl, in control group ‎respectively, which showed a significant difference between mean and standard ‎deviation of serum zinc and magnesium levels in both case and control groups. Based ‎on logistic regression analysis, the increase in serum zinc levels is associated with a ‎reduction in the depression risk [odds ratio: 1‎‏.‏‎027; CI 95%: 1‎‏.‏‎011 to 1‎‏.‏‎044]. Moreover, ‎the increase in serum magnesium levels is associated with a reduction in the ‎depression risk [odds ratio: 3/278; CI 95%: 1‎‏.‏‎62 to 6‎‏.‏‎602].‎ Conclusion: Based on the findings, serum zinc and magnesium levels in the case ‎group were lower than that of the control group. This valuable information can be used ‎in planning to prevent depression‎.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative