Inflammatory process caused by cholecystitis may be the reason for changing the functional tests of the liver, and these changes help reduce the risk of an Endoscopic Retrograde Cholangiopancreatography (ERCR) and predict stones in the bile ducts. The presented study was performed between October 2017 and December 2019 on 140 patients suffering from cholecystitis. This study sought to evaluate the role of liver function testing in diagnosing stones in the bile duct. Patients underwent surgically removing gallstones, then performing intravenous cholangiography for patients suspected of having biliary colic, and hepatic enzymes were measured from direct and total bilirubin, (ALP), Alanine Aminotransferases (ALT), and Aspartate Aminotrans ferases (ASTs) that were not mainly diagnosed. Based on the high level of hepatic enzymes, ALP, ALT, and AST did not have significant differences between the two study groups, so to make sure of the presence of stones, we rely on conducting ultrasound imaging before performing intravenous imaging of the bile duct ERCP.