Background: recent researches suggested that IBD is associated with changes in patients' quality of life (QOL). This study aimed at evaluating the QOL in patients with Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis) and its relation with some demographic and clinical variables in Ahvaz hospitals. Methods: In this epidemiological and descriptive-analytical study, 260 hospitalized and outpatient adults with inflammatory bowel disease (Crohn's disease and ulcerative colitis) in Ahvaz educational hospitals were evaluated by WHOQOL-BREF and the Demographic Information Questionnaire. And at the end, the obtained data were analyzed by SPSS version 22 software. Results: The subscale of physical health was calculated as 10.80±47.52, psychological subscale was 47.42±16.07, the subscale of social relations was 49.04±15.75, environment and the life status was 14.33 ±47.05 and the total score of the QOL scale was 68.68±12.47. The QOL of IBD patients in different age groups (p = 0.08) and gender (p = 0.53), as well as the type of disease (p = 0.11) did not show any significant differences while the variables such as marital status (p = 0.01), education (P = 0.005), income (p = 0.004), place of living (p = 0.001), duration of disease (p = 0.00), history of surgery (p = 0.02), and corticosteroid use (p = 0.03) had significant statistical changes in QOL of IBD patients. The QOL was higher in rural and single people, those with higher education and lower incomes, and those with corticosteroid use compared to the urban and married people with lower education and higher incomes (P <0.05). Conclusions: IBD patients need to manage the QOL because this disease can reduce the QOL. The risk factors such as marital status, education, income, place of living, duration of illness, history of surgery, and corticosteroid use have a statistically significant relationship with the QOL.
