The properties of erythrocytes strongly determine the course of the entire microcirculation and metabolism in the body. Elucidation of the state of students who had long-term low physical fitness and began to regularly perform feasible physical exercises can track the progress of optimization of erythrocyte parameters that are significant for microcirculation. The study involved 42 male students who had low physical activity throughout their future life and who began regular athletics training 3 times a week. The control group included 46 students who, for at least 7 years, regularly experienced athletics loads at least 3 times a week. The work uses standard proven biochemical, hematological, and statistical research methods. After six months of physical training in the blood of students, previously poorly physically trained, normalization of metabolites of arachidonic acid, a decrease in the amount of cholesterol and acyl hydroperoxides in erythrocytes, and an increase in the level of phospholipids in them. During these periods, the students who started training experienced an increase in the number of erythrocytes-discocytes and a decrease in the number of all altered forms of erythrocytes. For students with low physical activity, who began regular physical training, a gradual improvement in the surface properties of erythrocytes is characteristic, which facilitated the processes of microcirculation in tissues.