The work aimed to analyze the intensity of H3-type citrus in the blood of women with genital and breast cancer. Group 1 included 90 women with cancerous tumors of the uterus (26), ovaries (30), malignant neoplasms of the cervix (10), and mammary glands (24). Group 2 included 66 women who had benign tumors in the same locations. Heston levels were determined by the immunoassay method. Group 1 showed an elevated concentration of histone (from 1.4 to 2.1 ng per 1 ml), and Group 2 was normal (0.3-0.4 ng per 1 ml). Depending on the diagnosis, the concentration of citrules in patients with breast cancer was 0.3-0.9 ng per 1 ml, in those with ovarian cancer 1.3-2.1 ng per 1 ml, and in those with uterine cancer 2.2-3.0 ng per 1 ml. The parameters of C-reactive protein and D-dimer concentration were also increased at higher values of histone concentration. Increased content of neutrophils, and platelets. The presence of increased ketosis activity was found in women in group 1, with a diagnosis of uterine and ovarian cancer.