Background and Objectives: A few studies have conducted on the effect of protein and creatine supplementation combined with resistance training on the fitness, speed, and strength and muscle hypertrophy of untrained young women. The purpose of the present study was investigating the effect of whey protein, creatine supplements and resistance training on fitness, velocity and muscle hypertrophy in untrained young women. Materials and Methods: The present study was as a quasi-experimental. Thirty-sixth non-active healthy women (weight 61.39±5.92 kg, age 23.91±1.89 year) volunteered to participate in this research. They were randomly assign into three groups: Experimental group 1: Supplementation (protein 1260gr and creatine 450gr) + 6 weeks of strength training, Experimental group 2: placebo + 6 weeks of strength training, and control group. Duration of training was 6 weeks; 4 sessions per week, and each session lasted 50-70 minutes with the intensity of 60-75 percent of maximal reserve heart rate. Data analysis with use of inferential statistics (repeated ANOVA, and Bonferroni post hoc test, when necessary) and employing the SPSS software (version 18). Significance level of p≤0/05 considered. Results: No significant changes in speed, percent body fat, and maximum oxygen uptake have occurred. A significant increase has observed in the maximum power in both groups of supplementation and placebo, and there was a significant increase in the Supplementation group in the variables of weight, BMI and muscle hypertrophy compared to the pre-test and the control groups, as well as the placebo group compared to the pre-test group. The variables of power and muscular endurance have increased no significantly in both groups of supplementation and placebo. Conclusion: Strength training alone can increase power, but to further increase the strength, weight and hypertrophy in heavy exercises, long-term consumption of supplements of creatine and protein recommended. A greater undersetting of these pathways and consequences of concurrent consumption protein and creatine supplementation in females might certainly boost their performance and could use as a dietary supplement to optimize and enhance health outcomes for women.
