Introduction: Comprehensive rehabilitation plays an important role in the care of burn. Joint motion exercises are part of the essential programs for the rehabilitation in burn injuries. This study was conducted to determine the effect of range of motion exercises on activity daily living and quality of life in patients with burn.Methods: The present clinical trial study was performed on 60 patients with second degree burns. Patients were randomly assigned to two groups of control and intervention, each with 30 subjects. Patients in the intervention group received scheduled range of motion exercises (Flexion- Extension, Abduction- Adduction, Internal rotation- External rotation) three times a day for 4 weeks in burn joint. The data were collected through Barthel's questionnaire and Burn Specific Health Scale. Student’s t-test and SPSS version 23.0 were used for statistical analysis.Results: The findings of the present study showed that there was a significant difference between the two groups in terms of the average activity daily living (P <0.001). Comparison of the dimensions of quality of life in the control and intervention groups based on independent t-test showed a significant difference in physical dimension (P <0.001), social dimension (P <0.001), and psychological dimension of quality of life (P = 0.01).Conclusion: The results of this study indicate the effective role of range of motion exercises on improving the activity daily living and quality of life of patients with burns in all aspects. Thus, it is recommended to use range of motion exercises in providing appropriate care for burn patients in hospitals and burn centers.