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2018 Volume 9 Issue 2 Special Issue

The Effect of Diazinon Poison on Changes in Testicular Tissue and Testosterone Hormone levels in NMRI Lab Mice


Saeid Salahi*, Reza Ghazanfari, Akbar Darwish, Rasoul Mazloumshahraki, Yunes Shakibzade, Hadi Kord, Sahar Bahari
Abstract

Background and purpose: Diazinon (DZN) is an organ phosphoric pesticide that can cause damage to the cells and tissues while producing oxidative stress. Therefore, this study was conducted to determine the effect of diazinon on testosterone and testicular tissues in mice. Materials and Methods: In this in-vitro study, 28 adult male mice with a mean age of 12 weeks were randomly divided into four groups: control, sham and experimental groups 1 and 2. Experimental groups 1 and 2 received diazinon toxin 0.5 and 1.5 mg / kg body weight for gavage for four weeks, respectively. The control group did not receive any substance, and the sham group received the solvent of the poison. The rats were killed seven days later and the testes were examined histologically. Concentration of testosterone was measured by radioimmunoassay method. Results: The number of germinal cells and tubes diameter of Seminifer in the experimental group 2 was significantly lower than the control group (P <0.05). Conclusion: The results indicate that testicular tissue is susceptible to diazinon and its effect is dependent on dose.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative