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2019 Volume 10 Issue 4

Synthesis, characterization, and Antibacterial Study of some Imidazole and Molecular Docking of New Heterocyclic from Furan Derivatives


Safaa Abdulhameed Dadoosh, Monther Faisal Mahdi and Abdul Jabar Kh. Atia
Abstract

New imidazole contents and thioxo-imidazolidin were synthesized by using simple methods. All compounds were synthesized by using the derivatives of aniline as starting materials, which were obtained from furfural and sodium nitrite. Hydrochloric acid derivatives (S6, S7) were obtained from the reaction of (S6, S7) with Thiosemicarbazide; while the reaction of (S13, S14) with chloroethyl acetate derivatives led to the formation of (S20, S21). The reaction of Benzene sulphonyl chloride with (S18, S19) Triethylamine led to the formation of (S25, S26). Finally, the reaction of acetyl chloride with (S27, S28) Triethylamine led to the formation of (S34, S35). FTIR, 1HNMR, and GC MASS spectra as well as molecular docking, were used to characterize the derivatives used as antibacterials and were tested against several bacterial species including S.aureus, S. epidermidis, Escherichia coli, and Klebsiella sp.

All the synthesized compounds having promising docking results with COX-2 active site as shown in compounds (S27, S20, S35, S34, S13, S28, and S21) showed H-bond interactions with Arg121 and Tyr356 and these two amino acids exist in the binding with five approved NSAIDs. These compounds have H-bond with Arg121 and Tyr356, which exist in the binding site of diclofenac, lumiracoxib, and tolfenamic acid.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

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FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative