The aim is to study the clinical profiles of patients with severe AP treated surgically during their stay in the hospital. Methods and materials: a result analysis of treating 125 patients with severe forms of acute pancreatitis was carried out. All patients in the preoperative period were imaged through ultrasound scanning (hereinafter referred to as the US). 40 patients were also imaged through computed tomography (hereinafter referred to as CT). US and CT data obtained before surgery were compared with intraoperative ones. Results: All patients were operated on. Operation indications involved: peritonitis clinical picture in 117 patients (93.6%), arosive vessel bleeding in the necrotizing and sequestrum area in 4 patients (3.2%), jaundice growth in 4 patients (3.2%). 80 patients showed infected pancreonecrosis, 80 patients showed retroperitoneal tissue disease. 34 patients died. Factors affecting the disease outcome were revealed: infected pancreonecrosis, retroperitoneal tissue disease, cachexia, obesity, alcoholism, coronary heart disease, arterial hypertension and hepatic disorders, total ASSES scores are higher than 13 upon admission and before surgery, as well as higher than 16 on the 1st-2nd and 3rd-4th day after the operation. Conclusion: The complex use of computed tomography and ultrasound when diagnosing severe forms of acute pancreatitis increases the informational value of these methods to almost 100%.