Introduction: Multilocular lesions are unique that can be either cystic or neoplastic. These lesions have different clinical, radiographical and histopathological views. The aim of this study was to investigate the clinical and radiographic findings of Multilocular lesions in panoramic images or other advanced imaging techniques such as CT or Cone-beam (CBCT) tomography. Materials and Methods: In this case-series study, Multilocular lesions with definitive biopsy results were investigated from the archives of a private radiology center and Mashhad dental school. Demographic data and their radiographic characteristics were examined. Results: Totally, 70 Multilocular lesions were categorized into 4 groups: cysts, benign tumors, malignant tumors, and Cherubism. The most common lesion in this study was CGCG (n=24 cases), and the most common age of involvement were the second decade. Of the total lesions, 27 cases was for men and 43 cases for women. Except one case of CGCG that was related to hyperparathyroidism and was multi-focal, all the other lesions were single-focal. Most of the lesions affected posterior of the mandible and the most common effects on the adjacent structures was tooth displacement. The Well-defined corticated border was the most common. Conclusion: Ameloblastoma, OKC, and CGCG were more common in women. The age distribution of ameloblastoma, OKC, CGCG, and myxoma was similar to other studies. Location Distribution of ameloblastoma, OKC, CGCG, and myxoma were more common in the mandible. The swelling was the most common effect on adjacent structures.
