Analysis of the structure of morbidity and prevalence of congenital malformations among children in the Osh region in 2018-2020. The database was compiled based on the results of the analysis of 950 medical records of children with congenital heart defects (aged 0 to 15 years 11 months) filled in during 2018-2020. Results: the authors have noted an increase in the number of boys and a decrease in the number of girls with congenital heart defects in 2020 compared to 2019 and 2018 (66.4% and 33.6%; 61.3% and 38.7%; 47.3% and 52.7%, respectively). There was a significant decrease (p <0.05) in the number of children aged 0 to 1 year (38.8% in 2020 versus 50.2% in 2018) and a significant (p <0.05) increase in the number of children in the age range 6 to 15 years old (21.1% in 2020 compared to 12.5% in 2018). Significantly more often (p <0.05) in 2018, 2019 and 2020, ventricular septal defect was registered (39.60%; 45.29% and 34.12% of cases, respectively). Conclusion: the study of the peculiarities of the dynamics of registered congenital heart defects among children of the Osh region in 2018-2020 taking into account gender and age characteristics is important for the development of organizational measures for diagnosis and treatment and will make it possible to create a congenital heart defects register in this region, the presence of which will ensure the monitoring of patients with congenital heart defects at every stage from registration to deregistration.