The authors have studied the influence of a probiotic and a gastrointestinal adsorbent on the histostructure of the digestive tract of broilers. Day-old broilers were divided into groups of 50 heads each by the method of analog pairs in terms of live weight. Control broilers received a basic diet. Broilers of the 1st experimental group during the first three days of the experiment received probiotic Vetom-1.1 (0.006%) containing spores of Bacillus subtilis with the basic diet, and broilers of the 2nd experimental group received gastrointestinal adsorbent Enterosgel (0.008%). For histological studies, three heads of broilers were selected at day 1 of age, day 4 of age, and at the end of the experiment (after the end of feeding the preparation and before the transition to the basic diet) from the average weight of each group. Samples were excised from the middle of the crop, the glandular part of the stomach, the duodenum, the jejunum, and the proximal part of the cecum of birds. At the end of the experiment, the positive aftereffect of the preparation persisted in the crop and duodenum. At the same time, in the experimental group, the thickness of the submucous membrane of the stomach decreased, and in the cecum, the layer of villi increased.