Aim: Investigate the corrolation between serum Vitamin D level and patient with wet and dry AMD in the comparision with normal patients.Methods: A total of 204 patients were enrolled, and were devided into three groups as: The wet (early) AMD group, dry (late) AMD group, and those without any macular degeneration (normal control group). We checked serum 25-hydroxyvitamin D levels of all subjects. Serum vitamin D deficiency was defined as a serum 25-hydroxyvitamin D level below 20ng/mL.Results: We analyzed whole data by multiple logistic regression analysis between the normal control group, and both early and late AMD groups. Serum vitamin D deficiency showed a tendency to increase the risk of late AMD, (OR=4.36; CI 95%; P =0.012). Serum vitamin D deficiency was also significantly associated with a increased risk of early AMD (OR= 4.78; CI 95%; P=0.008).Conclusion: serum vitamin D deficiency may increase the risk of early and late AMD. It may also be associated with subretinal fibrosis.
