Background: The current study aimed at surveying the screening test accuracy for G6PD (glucose-6-phosphate dehydrogenase) deficiency and the patients' parents information about the disease progression and persistence as determinant factors in hospital admissions of these patients in Shiraz, Southern part of Iran. Methodology: This study was conducted on 239 subjects with the final diagnosis of G6PD deficiency disease from April 2013 to July 2014. The data were obtained through their old chart review and also call interview with their parents. Patients' first hemoglobin level documented in the hospital was considered as the severity marker of the disease. Moreover, the numbers of packed cell RBC transfusions as the probable marker of illness complications and severity were recorded. Results: In the current research, 59.8% of parents were aware of their children`s disease diagnosis before hospital admission. The sensitivity of disease screening test (Fluorescent Spot Test) has been about 59.8% in the selected population. Most of the patients (41.84%) have been admitted with hemoglobin concentration between 5&7 mg/dl, whereas 50.2%, 23.43%, and 7.1% of them have had one, two and more than two times blood transfusion, respectively. Conclusions: The results of this study showed that parents’ information about the disease transient etiology and its improvement with aging were the main reasons for neglecting the condition. Due to complications of disease acute attacks, improvement of illness screening test sensitivity for earlier detection of the patients and screening centers of staff recommendations to take caregivers teachings about the persistent disease etiology and triggering factors should be considered more seriously.
