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2023 Volume 14 Issue 2

Recent Advances in the Development of novel inhibitors targeting RNA Helicase Enzyme of SARS-CoV-2


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Abstract

The rapid spread and infection rate of novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has created a worldwide pandemic since its origin in 2019. Another concern for improvement in controlling the infection is the non-availability of effective medications against the virus. So, these challenges generate the general scientific interest to focus on the development of novel drug molecules that can prevent viral propagation. The virus contains an RNA helicase enzyme known as nonstructural protein 13 (sp 13), a critical viral replication regulator. Hence this enzyme can be used as a target so that the potential inhibitor molecules can be used to stop its function. Furthermore, the virus is related to other members of the Coronaviridae family, for which inhibitor molecules are available. Recently, the crystallographic structure of the nsp13 of SARS-CoV-2 has been resolved and is available in the protein data bank (PDB). Hence, this information provides the opportunity to apply several computational and experimental approaches to elucidate the enzyme's functional aspects and help to propose new inhibitor molecules. Several natural products, synthetic compounds, and previously proven effective compounds have been studied for their binding affinity and inhibition properties of the molecule. This review presents the basic idea about the genomic arrangement and structural and functional aspects of the RNA helicase enzyme of SARS-CoV-2. Also, the inhibition strategies of the enzyme by the inhibitor molecules along with challenges have been highlighted by narrating the recent literature.


How to cite this article
Vancouver
Satpathy R, Acharya S. Recent Advances in the Development of novel inhibitors targeting RNA Helicase Enzyme of SARS-CoV-2. J Biochem Technol. 2023;14(2):66-74. https://doi.org/10.51847/Lp8N72wFgI
APA
Satpathy, R., & Acharya, S. (2023). Recent Advances in the Development of novel inhibitors targeting RNA Helicase Enzyme of SARS-CoV-2. Journal of Biochemical Technology, 14(2), 66-74. https://doi.org/10.51847/Lp8N72wFgI
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

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FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative