Introduction: Non-alcoholic fatty liver disease is currently recognized as one of the most common causes of chronic liver disease. The risk factors that are generally accepted for NAFLD are obesity, insulin resistance, hyperlipidemia and diabetes. The aim of this study is to find the estimated prevalence of NAFLD in the Iranian population. Method: This study is a cross sectional study conducted in 2016 in three central cities of Iran including Isfahan, Yazd and Shahrekord. Total 520 subjects were involved in this study by cluster random sampling. Blood samples were taken from each subject, and demographic and anthropometric information and risk factors were completed for individuals. The significance level for this study was P_value < 0.05. Result: The overall prevalence of NAFLD in three central provinces of Iran is 37.8%, the highest prevalence of NAFLD is %30.2 in Isfahan and the lowest prevalence of NAFLD is %20.9 in the city of Shahrekord.Also, The prevalence of NAFLD is higher in men than women. The prevalence of NAFLD is higher in the age group of 30 to 45 years. Conclusion: In our study, the overall prevalence of presumed NAFLD was determined at 37.8%. The rate of presumed NAFLD varies across dif¬ferent provinces. The prevalence was significantly higher in Isfahan and lower in Shahrekord. The presence of presumed NAFLD was signifi¬cantly associated with higher BMI.
