Objective: The study was designed to evaluate prescribing pattern, Medication Adherence and Quality of life associated with antihypertensive drugs in Geriatric patients in Dr. B. R. Ambedkar Medical College and Hospital, Bangalore, India. Methodology: A prospective and observational study was carried out for 6 months in Dr. B. R. Ambedkar Medical College and Hospital. A total of 120 patients were involved in the study. Prescribing pattern was evaluated by referring to patient case files comparing with JNC 7 guidelines. Patients medication adherence level was assessed by using Morisky medication adherence scale and quality of life by using MINICHAL questionnaire. After collection of complete data, appropriate descriptive and inferential statistical analysis was performed. Result: A Total of 120 patients were enrolled in the study both from in-patient and outpatient department. The commonly prescribed drug in both the department is CCB’s as single dug therapy, CCB’s account for 43.90 in In-Patient department, 66.66% in Out-patient department. Under combination therapy ARB + Diuretics was commonly prescribed 69.23% in In-patient & 70.74% in Out-patient department. Majority of the study population were having good quality of life and having high level of medication adherence towards the therapy. Conclusion: The most preferred prescribing therapy in both in-patient and out-patient was single drug therapy. Calcium Channel Blockers were the most frequently prescribed class of drugs in single drug therapy, Angiotensin Receptors blockers with Diuretics were the most commonly prescribed class of drugs in in-patient department and in out-patient department also Angiotensin Receptors blockers with Diuretics are the frequently prescribed combination of drugs. Majority of the study population were having the high level of adherence towards the anti-hypertensive therapy, which means they are in good compliance with the treatment and showed that many of the patients are having the good quality of life, we used MINIHCAL questionnaire to assess the quality of life of patients. Pharmacists situated as the most available health care providers in the community, could improve patient's information and adherence to the administration of BP. The hospital is in large compliance with JNC guidelines, in prescribing pattern of anti-hypertensive medications to the Geriatric patients.