The objective of the present research is Predicting the Self-Efficacy and Life Quality of Women Suffering from Breast Cancer based on Cognitive Emotion Regulation Strategies. The statistical population included all women who were suffering breast cancer and were undergoing treatment in Breast Cancer Research Center of Medical Sciences of University of Tehran. 78 of them were selected by convenience sampling and were assessed by using the questionnaires of cognitive emotion regulation strategies, self-efficacy and life quality. Then, the collected data were analyzed using multivariate regression. According to the attained findings, there is a significant relationship between cognitive emotion regulation strategies and self-efficacy and life quality of women suffering from breast cancer. In other words, cognitive emotion regulation strategies specify around 27.4% of changes of self-efficacy and about 23.9% of changes of life quality of the subjects.