In this research, an optimization of captopril electrochemical measurement with Box-Behnken and Taguchi experiments was performed using cyclic voltammetric method. Voltammograms were recorded using potentiostat-galvanostat Type III AUTOLABμ model (FRA2). In this study, a three-electrode system, a platinum electrode as the work electrode, a carbon electrode as auxiliary electrode and Ag / AgCl as a reference electrode were used. All experiments were carried out at room temperature. The effect of pH, scanning speed and electrolyte concentration were investigated and the pH = (1, 2, 3, 7) and scanning speed (0.3 - -0.1) V/s yielded the best results. Designing experiments and analyzing data was done using Minitab16 and Design-Expert 8.0.7.1 software based on the results of initial studies. The Box-Behnken design in this experiment could not provide optimal captopril measurements due to the lack of proper and reliable model, and Taguchi method, in addition to designing the experiment, provides optimal conditions for captopril measurement, which is also effective both in measuring concentration of electroactive material in a standard sample and in measuring the actual sample. The observed anodic peak current is equal to the captopril concentration in the ranges of 1 x 10-5 to 1 x 10-4 M in optimal linear conditions. The detection limit in this experiment is 1 x 10-8 M. Samples of captopril 25 mg tablets prepared from SOHA pharmaceuticals and were analyzed by Taguchi's proposed method, which yield favorable results.
