Opisthorchiasis is a natural focal zooanthroponosis that is widespread in many countries of the world and poses a serious threat to human health. The largest and most intense focus of opisthorchiasis in the world is the Ob-Irtysh, covering 10 territories and regions of Russia and Kazakhstan. The incidence of the population in Western Siberia reaches 51.82%, and in some areas - over 95%. The highest incidence index in Russia is observed among the indigenous coastal population. The incidence is noted among children aged 1–3 years, increases by the age of 14–15, and remains at this level until 50–60 years. To summarize the available literature data related to the epidemiology of opisthorchiasis, its high prevalence in various populations, the prognosis of the epidemiological situation, and social factors. According to the results of the review, Western Siberia should be considered a highly endemic region for opisthorchiasis in the Russian Federation. Helminthiases ranks fourth in terms of damage to public health. The absence of a specific clinical picture makes it difficult to diagnose opisthorchiasis. The predominance of the latent form leads to incomplete registration of all cases of invasion. The numerical scale of the disease indicates the global nature of the problem, which is becoming relevant today in practical medicine. In order to prevent opisthorchis, veterinary and sanitary education of the population about the danger of the disease and methods of disinfecting fish should be constantly carried out.
