Objective: One of the most confusing aspects of medical treatment of missed abortion is that till now there is no fixed and standard medical regimen suggested. The objective was to investigate the effectiveness of mifepristone/misoprostol regimen versus misoprostol only regimen in treatment of missed abortion at Kempegowda Institute of Medical Sciences, Bangalore, India. Methods: A non-interventional prospective study was conducted during a one-year study, 200 women were enrolled, each with a documented missed abortion < 13 weeks of gestation through ultrasound examination. Hundred women were administered 200 mg of oral mifepristone followed by two doses of 400 mcg of misoprostol with a four-hour gap. The rest of the subjects were administered 200 mcg of misoprostol every four hours up to four doses. Results: The effectiveness of treatment of missed abortion with mifepristone/misoprostol regimen was 93% while the effectiveness with misoprostol only regimen was 79% (p=0.004). Conclusion: Treatment of missed abortion with mifepristone/misoprostol regimen is more effective than treatment with misoprostol only regimen.
