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2021 Volume 12 Issue 4

Measurement of Fibrin Degradation Products (FDPs) among Patients with Cardiovascular Diseases: A significant Target for Prognosis


Alaa Eltayeb Omer, Abdel Rahim Mahmoud Muddathir, Lienda Bashier Eltayeb
Abstract

Fibrin degradation products have gained increasing interest. It is regarded as a crucial marker for the turnover of cross-linked fibrin and activation of the hemostatic system, specifically in cardiovascular diseases. So the current study aimed to measure the fibrin degradation products and other possible hazards in Sudanese patients with Acute Coronary Syndrome. A descriptive case-control study among 60 healthy controls with no history of heart disease, 60 with Myocardial Infarction (MI), 60 patients with Unstable Angina (UA), and 120 patients with Acute Coronary Syndrome. Venous blood samples were obtained from all participants on admission and gathered in Trisodium citrate depleted tubes. FDPs were measured by FDPs latex agglutination test. Results: A total of 180 participants aged from (30–70) years old, mean 49± 8.93 SD, there were no statistically significant differences considering gender and age among patients and control group. The FDPs were significantly higher in patients with ACS compared to a healthy population, FDPs were positive in 80 patients (67%). The mean ±SD of FDPs was significant among MI and UA consequently. There was a significant correlation between FDPs with hypertension, hyper-lipidaemia, diabetes mellitus, and family history for myocardial infarction and unstable angina. Conclusion: Elevated FDPS levels were revealed among Sudanese patients with Acute Coronary Syndrome (ACS), which may be a prognostic marker for thrombotic tendency. As a consequence, FDPs must be included in regular laboratory investigations, as well as the ACS monitoring strategy.


How to cite this article
Vancouver
Omer A E, Muddathir A R M, Eltayeb L B. Measurement of Fibrin Degradation Products (FDPs) among Patients with Cardiovascular Diseases: A significant Target for Prognosis. J Biochem Technol. 2021;12(4):23-8. https://doi.org/10.51847/l3nLVcnMMs
APA
Omer, A. E., Muddathir, A. R. M., & Eltayeb, L. B. (2021). Measurement of Fibrin Degradation Products (FDPs) among Patients with Cardiovascular Diseases: A significant Target for Prognosis. Journal Of Biochemical Technology, 12(4),23-28. https://doi.org/10.51847/l3nLVcnMMs
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative