Fibrin degradation products have gained increasing interest. It is regarded as a crucial marker for the turnover of cross-linked fibrin and activation of the hemostatic system, specifically in cardiovascular diseases. So the current study aimed to measure the fibrin degradation products and other possible hazards in Sudanese patients with Acute Coronary Syndrome. A descriptive case-control study among 60 healthy controls with no history of heart disease, 60 with Myocardial Infarction (MI), 60 patients with Unstable Angina (UA), and 120 patients with Acute Coronary Syndrome. Venous blood samples were obtained from all participants on admission and gathered in Trisodium citrate depleted tubes. FDPs were measured by FDPs latex agglutination test. Results: A total of 180 participants aged from (30–70) years old, mean 49± 8.93 SD, there were no statistically significant differences considering gender and age among patients and control group. The FDPs were significantly higher in patients with ACS compared to a healthy population, FDPs were positive in 80 patients (67%). The mean ±SD of FDPs was significant among MI and UA consequently. There was a significant correlation between FDPs with hypertension, hyper-lipidaemia, diabetes mellitus, and family history for myocardial infarction and unstable angina. Conclusion: Elevated FDPS levels were revealed among Sudanese patients with Acute Coronary Syndrome (ACS), which may be a prognostic marker for thrombotic tendency. As a consequence, FDPs must be included in regular laboratory investigations, as well as the ACS monitoring strategy.