Background: Liver cirrhosis is one of the most common complaints in the medical field. Many causes are identified to cause liver cirrhosis, such as alcohol, infections, or genetic causes. Many modalities can help in the diagnosis of liver cirrhosis, however, biopsy still the gold standard. Many complications can be a result of liver cirrhosis, portal hypertension is a common complication which needs to be identified and treated as early as possible. Treatment mainly depends on the cause, if the cause could be treated early, the liver injury could be reversed, and otherwise, it will be permanent and can be fatal. Objective: The objective of this review is to discuss Liver cirrhosis, pathophysiology, investigations, complications, and treatment in a general view. Method: We searched the PubMed database looking for relevant articles to the topic using Mesh terms, “liver cirrhosis ". Conclusion: Many causes are identified to cause Liver cirrhosis, for that, early detection of the cause and proper treatment could prevent liver cirrhosis and it is complications.