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2021 Volume 12 Issue 1

Latest Advances in Gene Therapy in Management of Cystic Fibrosis Lung Disease, Literature Review


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Abstract

Cystic fibrosis is an autosomal recessive disease that affects ion channels on epithelial cells. This leads to thicker and dysfunctional secretions. This can be evident when looking at the major symptoms of CF patients, which include recurrent respiratory tract infections and pancreatic insufficiency. The current management options for CF are either to manage the symptoms or modulate the existing defective genes. Gene therapy aims to correct dysfunctional genes as a way to cure the disease. We aimed to review the literature looking into gene therapy for cystic fibrosis, along with the advancements and current limitations. PubMed database was used for articles selection, papers were obtained and reviewed. There are multiple options for gene therapy in cystic fibrosis. This includes either introducing wild, working genes to the epithelial cells of the respiratory tract, or editing the defective genes. Gene replacement therapy is limited due to the nature of airway administration and the harsh environment of the airway of CF patients. Gene-editing therapy, however, is still under heavy research as it may offer a potential cure for this disease.


How to cite this article
Vancouver
Alghamdi SS, Alhamyani NM, Alamri HM, Alzahrani TS, Daghas SM, Bakri RH, et al. Latest Advances in Gene Therapy in Management of Cystic Fibrosis Lung Disease, Literature Review. J Biochem Technol. 2021;12(1):67-70. https://doi.org/10.51847/Usni3JotHd
APA
Alghamdi, S. S., Alhamyani, N. M., Alamri, H. M., Alzahrani, T. S., Daghas, S. M., Bakri, R. H., Basehi, A. F., Almarashi, A. S., Alrajehi, A. M., Al Ghanim, D. Z., et al. (2021). Latest Advances in Gene Therapy in Management of Cystic Fibrosis Lung Disease, Literature Review. Journal of Biochemical Technology, 12(1), 67-70. https://doi.org/10.51847/Usni3JotHd
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative