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2020 Volume 11 Issue 1

Isolation and Genetic Identification of L-Asparaginase Antitumor from Streptomyces sp.


Alzahrani N. H., Alzahrani S. H., Khayyat S. KH.
Abstract

L-asparaginase (L-asparagine amidohydrolase, E.C.3.5.1.1) is a supplementary cellular enzyme used as an anticancer substance. 31 Streptomyces strains isolated from rhizosphere of some plants in different regions of Saudi Arabia. The highest 11 Streptomyces isolates in L-asparaginase activity were selected for further molecular analysis based on differences in 16S rRNA gene sequence. Alignment analysis using the BLAST tools confirmed that all isolates are related to Streptomyces with a similarity of 97% to 100%.  And partial-length gene sequence was sentinto NCBI Gen Bank and received the accession numbers (Streptomyces griseoruben MN588164, Streptomyces alboflavus MN588165, Streptomyces werraensis MN588166, Streptomyces spororaveus MN588167, Streptomyces chryseus MN588168, Streptomyces globosus MN588169, Streptomyces roseolilacinus MN588170, Streptomyces xanthophaeus MN588171, Streptomyces lavendulae MN588172, Streptomyces tuirus MN588174, and Streptomyces tendae MN588175).


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative