The plant extracts are found to be effective against oxidative stress. There are lots of reasons for increased oxidative stress in which environmental factors and life style play a big role. In this study the herbal extracts of Saliva triloba, and Origanum syriacum used to study antioxidant properties compared to paracetamol. A total of 27 volunteers were divided into 3 groups, 2 groups took 250 ml of aqueous extract of S. triloba, and O. syriacum for 5 days and 3rd group took paracetamol 500 mg, each tablet twice a day for five days. Blood specimens were collected before taking extract and one hour after taking the first dose at day one and one day after the last dose. Serum Total Antioxidant Status (TAS) and reduced glutathione (GSH), malondialdehyde (MDA) and Superoxide Dismutase (SOD) in RBCs were tested. The oral intake of aqueous extract of the plants for five days increased serum TAS and GSH in RBCs compared to zero time of intake. In addition, oral intake of aqueous extracts of Saliva triloba for five days increased significantly, P value ≤ 0.05 the activity of SOD in RBCs as compared to zero time of administration. The herbs extracts of Saliva triloba and Origanum syriacum have anti-oxidant property compared to paracetamol, so as medicinal herbs with antioxidant effects can inhibit produced oxidative effects.
