This research deals with the organic extracts impact of Bunium incrassatum on the immune expression of estrogen receptors that is the assessment of the effect of organic extracts from the seeds of Bunium incrassatum (Apiaceae) on the immune labelling of estrogen receptors in the adrenal gland of pregnant rabbits from the local population (Oryctolagus cuniculus).The work was carried out on pregnant rabbits during the last third of gestation (from day 17 to day 27 of gestation). The animals were divided into four groups which received daily oral doses: 50, 100, and 200 mg/kg/day, respectively. The group with dose 0 was taken as a control. After treatment, the rabbits were sacrificed (28th day of gestation). Their organs were removed, defatted, and weighed then fixed in 10% formalin and the blood was collected in tubes with heparin. For immunohistochemistry, mouse monoclonal antibodies were used to determine the ER presence in the adrenal gland of rabbits. Theresults indicated that treatment with organic extract of Bunium incrassatum induced an increased rate of change in the thickness of the adrenal cortex in the treated groups compared to the control. A strong immune expression of estrogen receptors was observed in the groups treated with 50 and 100 mg / kg / day compared to the group treated with 200 mg/ kg/day. It can be concluded that estradiol has a direct effect on adrenal function in pregnant rabbits. Likewise, the components of the organic extract from the roots of Bunium incrassatum have modulatory activities for ER.