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2021 Volume 12 Issue 2

Immunolocalization of Adrenal Estrogen Receptors (ERs) In Pregnant Rabbits Treated with Organic Extract of Bunium incrassatum


Naoual Hammoudi, Souad Boulahbel, Sana Chentouh, Yasmina Bentayeb, Hind Djebaili, Amina Wissame Hadjeris, Noureddine Gherraf
Abstract

This research deals with the organic extracts impact of Bunium incrassatum on the immune expression of estrogen receptors that is the assessment of the effect of organic extracts from the seeds of Bunium incrassatum (Apiaceae) on the immune labelling of estrogen receptors in the adrenal gland of pregnant rabbits from the local population (Oryctolagus cuniculus).The work was carried out on pregnant rabbits during the last third of gestation (from day 17 to day 27 of gestation). The animals were divided into four groups which received daily oral doses: 50, 100, and 200 mg/kg/day, respectively. The group with dose 0 was taken as a control. After treatment, the rabbits were sacrificed (28th day of gestation). Their organs were removed, defatted, and weighed then fixed in 10% formalin and the blood was collected in tubes with heparin. For immunohistochemistry, mouse monoclonal antibodies were used to determine the ER presence in the adrenal gland of rabbits. Theresults indicated that treatment with organic extract of Bunium incrassatum induced an increased rate of change in the thickness of the adrenal cortex in the treated groups compared to the control. A strong immune expression of estrogen receptors was observed in the groups treated with 50 and 100 mg / kg / day compared to the group treated with 200 mg/ kg/day. It can be concluded that estradiol has a direct effect on adrenal function in pregnant rabbits. Likewise, the components of the organic extract from the roots of Bunium incrassatum have modulatory activities for ER.


How to cite this article
Vancouver
Hammoudi N, Boulahbel S, Chentouh S, Bentayeb Y, Djebaili H, Hadjeris A W, et al. Immunolocalization of Adrenal Estrogen Receptors (ERs) In Pregnant Rabbits Treated with Organic Extract of Bunium incrassatum. J Biochem Technol. 2021;12(2):24-32. https://doi.org/10.51847/80jYiklt8c
APA
Hammoudi, N., Boulahbel, S., Chentouh, S., Bentayeb, Y., Djebaili, H., Hadjeris, A. W., & et al (2021). Immunolocalization of Adrenal Estrogen Receptors (ERs) In Pregnant Rabbits Treated with Organic Extract of Bunium incrassatum. Journal Of Biochemical Technology, 12(2),24-32. https://doi.org/10.51847/80jYiklt8c
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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