Purpose: To evaluate the influence of corneal biomechanical properties and central corneal thickness on intraocular pressure measurements in children with aphakic glaucoma and primary congenital glaucoma. Methods: This comparative cross-sectional study consists of 70 eyes of 70 patients with aphakic (n=34) and primary congenital glaucoma (n=36) who referred for routine eye examinations. The intraocular pressure (IOP) and corneal biomechanical factors like corneal hysteresis (CH) and corneal Resistance Factor (CRF) were measured by Ocular Response Analyzer (ORA). Central corneal thickness (CCT) was checked by ultrasound pachymetry. Results: There was no statistically significant difference between the two groups for age (P=0.137), sex (P>0.05) and IOPcc (P-value=0.36). There were significant differences between CRF (p-value=0.001), CCT (p-value=0.0001) and CH (P-value=0.005) between groups. The regression equation of IOPg (goldman applantation tonometry) in aphakic group was
1.03CH (P<0.0001)+1.56CRF(P<0.0001)+0.077CCT(P=0.017) and in primary congenital glaucomatous group was -1.06CH(P<0.0001)+1.21CRF(P<0.0001)-0.03CCT(P=0.333)
Conclusion: CH, CRF, and CCT were significantly different between groups. CH and CRF were more effective than CCT for the accurate estimation of IOP in both groups.
