Under observation were taken 39 young men studying at the university, throughout their lives, who had low muscle activity and started systematic volleyball training 3 times during the week. The control group included 35 young men studying at the university, who for at least the last 2 years systematically participated in volleyball training at least 3 times a week. During the study, traditional biochemical, thematic, and statistical methods for obtaining scientific information were used. After six months of regular physical training in the blood of young men, there was a normalization of the content of products synthesized from arachidonic acid, a decrease in the content of cholesterol molecules, and acyl hydroperoxides in the erythrocyte membranes with an increase in the number of phospholipids. By the end of the observation in the blood of young men who started volleyball training, there was an increase in the number of discoid erythrocytes and a decrease in the content of erythrocytes with a changed shape. It can be assumed that with an increase in the level of muscle activity due to systematic volleyball training, previously physically untrained young men develop optimization of the surface characteristics of erythrocytes, which can facilitate microcirculation and metabolism throughout the body.