Schizophrenia is a disease that known by unknown foundations and main underlie of genetics and environmental factors. Acute infection with Toxoplasma gondii can cause similar psychotic symptoms of schizophrenia so that in adults, serum antibody levels against T. Gondii are associated with changes in behavior and psycho-motor skills. Therefore, the aim of this study was to determine the relationship between the sera level of IgG and IgM immunoglobulins associated with Toxoplasma Gondii infectious and schizophrenia. Accordingly, the subjects of this study were included 84 patients of both genders include male and female who were hospitalized to the Tehran's Razi Hospital based on the diagnosis of schizophrenia and 84 healthy subjects as the control group. the gender, age, marital status and hospitalization history information of all the subjects were obtained by a questionnaire and the sera assayed according to the ELISA kits procedure and by Antibody capture method. The mean of IgG but not IgM immunoglobulins in schizophrenic group was only increased significantly compared to the control groups. Also there is a significant inverse correlation between hospitalization time and level of sera IgG based on the Pearson test but there is no significant difference between the sexes (male and female) in terms of the IgG and IgM antibody level based on Independent T-test. Regarding the results, it can be concluded that the increased mean levels of antibodies against Toxoplasma, reflecting the association of Toxoplasma gondii infection and the incidence of schizophrenia.
