Introduction: Portal vein thrombosis is one of the most important complications of cirrhosis, which is associated with hepatocellular carcinoma. As portal vein thrombosis (PVT) can be a major cause of death in cirrhosis patients, especially those who are waiting for transplantation, its early diagnosis and timely treatment are necessary. The objective of this research was to evaluate the relationship between MELD Score and development of cirrhosis and portal vein thrombosis.Methodology: In this cross-sectional research, patients with liver cirrhosis admitted to Imam Khomeini Hospital in Urmia were evaluated. After performing Color Doppler sonography of portal vein, the MELD Score of patients was calculated and the obtained data were analyzed using SPSS 20 software.Results: In this research, 103 patients with liver cirrhosis hospitalized in the internal units of Imam Khomeini Hospital in Urmia were evaluated. Out of these patients, 20.4% had portal vein thrombosis and 79.6% had no portal vein thrombosis. In the MELD Score classification into two groups of less than 13 and more than 13, portal vein thrombosis in the first group (less than 13) was 28.6% and in the group of more than 13, it was 71.4%. The results revealed that with increasing MELD Score more than 13, the percentage of patients with portal vein thrombosis increases, and portal vein thrombosis is significantly associated with MELD Score above 13.Conclusion: owing to development of thrombosis in lower MELD Scores and the possible effects and complications of liver disease development following liver vein thrombosis, we should not wait for higher MELD Score in follow up of these patients and the patients should be diagnosed and treated timely.