Introduction: in one hand, given the importance of decision making and creativity in protecting and maintaining the life and safety of patients in health care system by medical emergency technicians, preventing the waste of time and providing the best care and outcome for patients, and as two factors of proper decision making and creativity are considered as the main professional competencies in the area of medical emergency, on the other hand, considering the useful and constructive effects and the importance of the role of the problem solving skills training in coping with stress and negative events, this study was conducted to evaluate the effect of problem solving based training on the decision making and creativity of the students of medical emergency department.Method: This research is a clinical trial, in which 50 medical emergency students were randomly assigned to control and intervention groups. At the beginning of the study, subjects of both groups completed the Scott and Bruce's Decision Making Questionnaire and 60-items Abedi's Creativity Questionnaire. After intervention (holding problem solving skills training workshop), which was performed for 8 weeks and once per week by, subjects of both group re-completed the questionnaires. Finally, two groups were compared.Results: The mean score of creativity before problem solving skill training in intervention and control groups was 54.88 and 54.64, respectively. After intervention, it was 160.56 and 66.48 in the intervention and control groups, respectively, which was statistically significant only in the intervention group (p-value <0.001) and the mean score of the decision-making in the intervention and control group was 44.14 and 39.20, respectively. After the intervention and at the end of the study, it was 104.12 and 58.00 in the intervention and control groups, respectively, which was statistically significant only in the intervention group (P-value <0.001).Conclusion: based on the results, problem solving methods training can increase the level of creativity and decision-making power of medical emergency department’s students and can be used as one of the cost-effective methods for periodic training in medical emergency.