Quick access

Share Article:
2019 Volume 10 Issue 2

Evaluation of Histopathological Changes of Oral Mucosa and Salivary Glands ‎in Model of Demyelination (Multiple Sclerosis) in C57BL/6 Mouse

Mehrshad Mohammadi, Khadijeh Abdal, Marzieh Darvishi, Parvin Eliasi, Ardeshir ‎Moayeri

Introduction: Multiple sclerosis (MS) is an autoimmune disease, which is characterized by multifocal demyelination of axons in the CNS. Complications due to the disease, as well as the use of immunosuppressive drugs, antidepressants, etc., lead to some abnormalities. These drugs predispose to oral bleeding and are particularly susceptible to infection. The main side effects of drugs in the oral cavity are stomatitis, ulcers, gingivitis, candidiasis, and some opportunistic infections (such as herpes simplex). Dentists should also be aware of the importance of the disease in the diagnosis, treatment, and prognosis of some lesions as well as its specific conditions. Hence, in this study, the histopathological changes of the oral mucosa and salivary glands were studied on C57BL/6 demyelination mice (multiple sclerosis model).Material & method: The histological changes in parotid, submandibular, and sublingual glands were studied in both control (intact) and demyelination models of mice. The present study, 20 mice C57BL/6 were divided into two groups: 1) sham group (fed regular chow); 2) demyelination group (received rodent chow mixed with 0.2% cuprizone for 12 weeks). Seven weeks after demyelination inflammation (Hematoxylin-eosin), fibrosis (Masson’s Trichrome), and mast cells granulation (toluidine blue) were examined. Result: Our results demonstrated inflammation in the major salivary gland 12 weeks after demyelination. Also, the increase in fibrosis and decrease in vascularization was observed in buccal mucosa of different areas (P<0.05). The keratinization reduced in demyelination group (P<0.05). The expression of GFAP in the major salivary gland was significantly decreased in the demyelination group (P<0.05). Conclusions: MS may be a risk factor for oral lesions such as inflammation, fibrosis, and ulcer. These data present the pathological effect of demyelination on acini and ductal region in salivary glands‎‎‎.

SCIRUS, Chemical Abstracts, EBSCOhost databases, Genamics JournalSeek, ABCD Journl Index, Asian Science Citation Index (ASCI) and many other international scientific databases.

Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

Publish with us

Deniz Publication
Guzelyali Mah. Sahilyolu Cad.Defne Sok. No: 7, 34903 Pendik, Istanbul
Email: [email protected]
Tell: +905344990778

Publishing steps

your paper
and revise
your research
and promote
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative