Objective: Many traditional medicine approaches are still preferable. One of the most worldwide utilized methods of traditional medicine is cupping therapy. Although cupping therapy is being used routinely in Persian Medicine (Unani Medicine), all the beneficial result of this procedure has not been proven. In this study, we are aiming to examine the effect of wet cupping therapy (WCT), type of bloodletting, on the health level and hematology factors (CBC parameters) in some healthy people in the city of Mashhad. Methods: Participants are divided randomly into two groups of 41 men in WCT group and 40 men in control group (CG). Blood was taken once before the intervention also one week and four weeks after the intervention to measure hematological factors. The Persian version of general health questionnaire -28(GHQ-28) was used to analyze the effect of this intervention on quality of life. Results: The study results were demonstrated that WCT has a positive effect on health level (P=0.001). Hemoglobin (HB), mean corpuscular hemoglobin (MCH) and Mean corpuscular hemoglobin concentration (MCHC) were decreased significantly in the WCT group after the procedure (P=0.001). Improving the health level had a positive correlation with decreasing the HB, MCH and MCHC. Conclusions: Our results demonstrated the beneficial effect of WCT on health. Blood viscosity changes after wet cupping therapy may cause health improvement due to decreasing the HB rate. It is suggested that WCT may be used to enhance physical and psychological health.
