Introduction and project introduction: Neonatal intestinal obstruction (NIO) is the commonest neonatal emergency surgery, so that 1 in every 2000 live births is estimated to have CIO. This problem is caused by multiple conditions, and the treatment outcome depends on the time of diagnosis and appropriate intervention. Methods: The study was retrospective with a review of the records of all hospitalized patients with CIO diagnosis at NICU of Imam Khomeini Hospital of Ahvaz. Obstruction symptoms and clinical presentations have been classified and studied in several commonly used groups in similar studies. Results: The most common cause of obstruction in the case group was in intestinal atresia with 46.6%, followed by imperforated anus (15.5%), intestinal malrotations (12.1%), hirschsprung (11.2%), meconium ileus (8.6%) and other causes of obstruction (6%). Distension exists in 34.5% of the patients studied in population. Vomiting in this study existed in 81.9% of patients and meconium deficiency in 56% of neonates.