The aim of this study was to evaluate the effects of omega-3 and Zn supplements on liver markers SGPT (Serum glutamic pyruvic transaminase), SGOT(Serum glutamic oxaloacetic transaminase), ALP(Alkaline phosphatase), GGT(gamma-glutamyl transpeptidase), bilirubin and serum albumin and kidney markers (creatinine, uric acid and blood urea) in patients with type 2 diabetes. A randomized, double-blind, placebo-controlled, trial in patients with T2DM. Participants received zinc (30 mg/d) and/or omega 3 (1g/d fish oil) for 8 weeks. There was a significant decrease in SGOT blood levels in all three intervention groups, compared to the beginning of the study after 2 months (P=<0.001). Also the effect of Zn supplement was significant on the average SGOT change (P=0.013). The effect of omega-3 and Zn supplements on the average change in SGPT was significant (P <0.001). After two months of intervention, serum levels of GGT decreased significantly in Zn group and Zn with omega-3 group (P=0.045, P=0.004, respectively). No significant findings were found regarding other liver markers (P> 0.05). There was a significant reduction in the uric acid after intervention in zinc group (P >0/001). Our data indicated that Zn and omega-3 supplements alone or together can improve liver function in type 2 diabetic patients. There was no significant effect on kidney markers with omega-3 supplements.
