Background: The aim of this study was to evaluate and compare the effect of dietary supplements of zinc and omega 3 separately and together on the lipid profile, inflammatory condition (hs-Crp) and total antioxidant capacity (TAC) in type 2 diabetic patients. Methods: In this, double-blind, randomized controlled trial, 100 type 2 diabetic patients were randomly divided into four groups: omega-3 (n =25 patients, 1,000mg of omega-3), zinc group (n =25, 30 mg zinc gluconate), zinc plus omega-3 group (n =25) and placebo group (n =25). They were followed for a two-month period. Results: After 2 months, a significant increase in total antioxidant capacity was observed in all the intervention groups (P <0.001). On the other hand, it can be stated that the highest amount of total antioxidant capacity increase was observed in omega-3 plus zinc supplementation group (0/313 units). Intra-group comparisons showed significant reduction of hs-CRP levels before and after intervention in intervention groups. Also, LDL blood levels in the groups receiving zinc and zinc plus omega-3, were significantly decreased after the study (P = 0.000, P = 0.0001, respectively). Conclusion: Our study results suggest that zinc supplementation plus omega-3 can have a beneficial effect on increasing the antioxidant capacity of diabetic patients. Zinc supplementation also enhances the effect of omega-3 in reducing triglycerides (TG) and Low-density lipoprotein (LDL) in the blood. Also taking omega-3 alone or with zinc supplements can help reduce inflammation in the body.
